Buy Methylphenidate (Ritalin) online

Buy Ritalin (Methylphenidate HCl) psychostimulant medication
Cheap qualitative Methylphenidate 10 mg, 20 mg tablets online



Carcinogenesis, Mutagenesis, Impairment of Fertility

In a lifetime carcinogenicity study carried out in B6C3F1 mice, Methylphenidate HCl (Ritalin) tablets caused an increase in hepatocellular adenomas and, in males only, an increase in hepatoblastomas, at a daily dose of approximately 60 mg/kg/day. This dose is approximately 30 times and 4 times the maximum recommended human dose on a mg/kg and mg/m2 basis, respectively. Hepatoblastoma is a relatively rare rodent malignant tumor type. There was no increase in total malignant hepatic tumors. The mouse strain used is sensitive to the development of hepatic tumors, and the significance of these results to humans is unknown.

Ritalin (Methylphenidate) did not cause any increases in tumors in a lifetime carcinogenicity study carried out in F344 rats; the highest dose used was approximately 45 mg/kg/day, which is approximately 22 times and 5 times the maximum recommended human dose on a mg/kg and mg/m2 basis, respectively.

In a 24-week carcinogenicity study in the transgenic mouse strain p53+/-, which is sensitive to genotoxic carcinogens, there was no evidence of carcinogenicity. Male and female mice were fed diets containing the same concentration of methylphenidate as in the lifetime carcinogenicity study; the high-dose groups were exposed to 60-74 mg/kg/day of methylphenidate.

Ritalin (Methylphenidate) tablets were not mutagenic in the in vitro Ames reverse mutation assay or in the in vitro mouse lymphoma cell forward mutation assay. Sister chromatid exchanges and chromosome aberrations were increased, indicative of a weak clastogenic response, in an in vitro assay in cultured Chinese Hamster Ovary (CHO) cells. Methylphenidate was negative in vivo in males and females in the mouse bone marrow micronucleus assay.

Methylphenidate Hydrochloride (Ritalin) did not impair fertility in male or female mice that were fed diets containing the drug in an 18-week Continuous Breeding study. The study was conducted at doses up to 160 mg/kg/day, approximately 80-fold and 8-fold the highest recommended dose on a mg/kg and mg/m2 basis, respectively.

Ritalin and Ritalin-SR (Methylphenidate Hydrochloride) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Strattera (Atomoxetine) nonclinical toxicology - Atomoxetine Hydrochloride
  • Capsules; Oral; Atomoxetine Hydrochloride 40 mg
  • Capsules; Oral; Atomoxetine Hydrochloride 80 mg
  • Eli Lilly
  • Four Star
  • Y.C. Woo
  • Zuellig Pharma
  • Bontril PDM prescribing information - Phendimetrazine Tartrate
  • Tablets; Oral; Phendimetrazine Tartrate 35 mg
  • Valeant Pharmaceuticals
  • Nuvigil nonclinical toxicology - Armodafinil
  • Tablets; Oral; Armodafinil 100 mg
  • Tablets; Oral; Armodafinil 150 mg
  • Cephalon
  • A-S Medication Solutions
  • Stat Rx USA

  • Recent posts:

  • Buy Ritalin (Methylphenidate) Online
  • Ritalin and Ritalin-SR prescribing information

    Copyright © Buy Methylphenidate Online