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RITALIN AND RITALIN-SR (METHYLPHENIDATE) TABLETS: OVERDOSAGE

Signs and symptoms of acute overdosage, resulting principally from overstimulation of the central nervous system and from excessive sympathomimetic effects, may include the following: agitation, vomiting, tremors, muscle twitching, hyperreflexia, convulsions (may be followed by coma), confusion, euphoria, hallucinations, sweating, delirium, flushing, hyperpyrexia, headache, tachycardia, cardiac arrhythmias, palpitations, hypertension, mydriasis, and dryness of mucous membranes.

Consult with a Certified Poison Control Center regarding treatment for up-to-date guidance and advice.

Treatment consists of appropriate supportive measures. The patient must be protected against self-injury and against external stimuli that would aggravate overstimulation already present. Gastric contents may be evacuated by gastric lavage. In the presence of severe intoxication, use a carefully titrated dosage of a short-acting barbiturate before performing gastric lavage. Other measures to detoxify the gut include administration of activated charcoal and a cathartic.

Intensive care must be provided to maintain adequate circulation and respiratory exchange; external cooling procedures may be required for hyperpyrexia.

Efficacy of peritoneal dialysis or extracorporeal hemodialysis for Methylphenidate (Ritalin) tablets overdosage has not been established.



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